Thursday, November 6, 2014

关于PD-L1的不解之处,请免疫学达人解惑

http://www.mitbbs.com/article_t/Biology/31923265.html

发信人: PRCROCer (民国公民), 信区: Biology
标  题: 关于PD-L1的不解之处,请免疫学达人解惑
发信站: BBS 未名空间站 (Thu Nov  6 04:50:30 2014, 美东)

PD-L1或者B7-H1在发现之初,两个小组给出了截然不同的结果。日本的小组说PD-L1抑
制T细胞的增值和细胞因子的释放
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member
leads to negative regulation of lymphocyte activation.
而Lieping Chen小组最早发现的时候说是刺激T细胞的增殖和细胞因子的释放:
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation
and interleukin-10 secretion
这样截然不同的结果有可能是分别在不同条件下都成立吗?还是说有一方错了?

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